A bicuculline-resistant inhibitory post-synaptic potential in rat hippocampal pyramidal cells in vitro.

Characteristics of a slow hyperpolarizing synaptic potential in rat hippocampal pyramidal cells in vitro.

An orthodromically evoked late hyperpolarizing potential (LHP) was studied using intracellular recording techniques in rat hippocampal CA1 pyramidal cells in vitro. Several tests indicated that the LHP is not blocked by GABA antagonists, but rather comprises the initial portion of the stimulation-induced burst afterhyperpolarization (AHPs) produced in the presence of these antagonists. Bath app...

Morphine and opioid peptides reduce inhibitory synaptic potentials in hippocampal pyramidal cells in vitro without alteration of membrane potential.

We used intracellular recording in the hippocampal slice in vitro to characterize further the mechanisms behind the unusual excitatory action of opiates and opioid peptides on hippocampal pyramidal cells in vivo. No significant effect on resting membrane potential, input resistance, or action potential size in cortical area 1 (CA1) pyramidal cells was observed with morphine sulfate, beta-endorp...

effects of low frequency stimulation on spontaneous inhibitory and excitatory post-synaptic currents in hippocampal ca1 pyramidal cells of kindled rats

objective: low-frequency stimulation (lfs) exerts suppressive effects in kindled animals. it is believed that overstimulated glutamatergic and decreased gabaergic transmission have long been associated with seizure activity. in this study, we investigated the effect of electrical lfs on different parameters of spontaneous excitatory and inhibitory post-synaptic currents (sepscs and sipscs) in h...

Endogenously released opioids inhibit inhibitory post synaptic potentials in guinea pig CA3 pyramidal cells and rat dentate granule cells.

Blocker-resistant Ca2+ currents in rat CA1 hippocampal pyramidal neurons.

Ca(2+) currents resistant to organic Ca(2+) channel antagonists are present in different types of central neurons. Here, we describe the properties of such currents in CA1 neurons acutely dissociated from rat hippocampus. Blocker-resistant Ca(2+) currents were isolated by combined application of N-, P/Q- and L-type Ca(2+) current antagonists (omega-conotoxin GVIA 2 microM; omega-conotoxin MVIIC...